Smith M E, Flynn F W
Department of Psychology, University of Wyoming, Laramie 82071.
Brain Res. 1994 Nov 28;665(1):123-6. doi: 10.1016/0006-8993(94)91160-6.
Intracerebroventricular (i.c.v.) injections of tachykinin NK3 receptor agonists suppress NaCl intake by sodium deficient rats. The brief exposure, taste reactivity test was used to examine the effect of tachykinins on the immediate, oral reinforcing properties of NaCl (0.5 M) in sodium replete and sodium deficient male rats. In sodium replete rats, intraoral infusions of NaCl elicited a mixed response comprised of a similar number of ingestive and aversive responses following i.c.v. injections of saline and succinyl-[Asp6,N-Me-Phe8]substance P, (6-11), (SENK), a NK3 receptor agonist. When sodium deficient, saline injected rats showed a reliable increase in ingestive and a decrease in aversive taste reactivity responses. Lateral i.c.v. injections of SENK blocked the shift in taste reactivity responses by sodium deficient rats, indicating that concentrated NaCl retained its aversive taste property.
脑室内注射速激肽NK3受体激动剂可抑制缺钠大鼠的氯化钠摄入。采用短暂暴露味觉反应测试，以研究速激肽对钠充足和缺钠雄性大鼠中氯化钠（0.5 M）即时口腔强化特性的影响。在钠充足的大鼠中，脑室内注射生理盐水和速激肽NK3受体激动剂琥珀酰-[天冬氨酸6，N-甲基苯丙氨酸8]物质P（6-11）（SENK）后，口腔内输注氯化钠引发了由相似数量的摄取性反应和厌恶反应组成的混合反应。缺钠时，注射生理盐水的大鼠摄取性反应可靠增加，厌恶味觉反应减少。脑室内外侧注射SENK可阻断缺钠大鼠味觉反应的转变，表明浓缩氯化钠保留了其厌恶味觉特性。
