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[远距离放射治疗在甲状腺肿瘤治疗中的应用]

[Teleradiotherapy in the treatment of thyroid neoplasms].

作者信息

Zorat P L, Calzavara F

出版信息

Chir Ital. 1994;46(4):61-5.

PMID:7533668
Abstract

The role of external radiotherapy in the treatment of thyroid neoplasms is not yet well defined. The indications for loco-regional treatment in the case of: anaplastic carcinomas (alone or in combination with surgery or chemotherapy); differentiated and medullary carcinomas at diagnosis or relapse; nodes or osseous metastases not otherwise curable (surgery, hormones, brachytherapy); cerebral metastases; are accepted by everyone. Results, from the various clinical reports published, are positive. The use of this methodology is not accepted by everyone as "adjuvant" in cases "at risk" for micro or macroscopic residuals after surgery for papillary, follicular or medullary carcinomas. From the analysis of the literature, even a recent publication in relation to an apparent growing local control, we have no data in favour of increased survival. Even from our experience we cannot give definitive data (78.5% of local control in case of papillary or follicular carcinoma, survival of 57% in 5 years and 36% in 10 years). The question could be solved only by randomised trials but the difficulties due to the need for a sufficient number of cases and to the long "natural" survival, even in presence of disease, appear to be insuperable. We suggest a prudent approach, in controversial cases, because of the difficulties linked to the optimal loco-regional treatment (high doses, proximity of organs "at risk").

摘要

外照射放疗在甲状腺肿瘤治疗中的作用尚未明确界定。对于以下情况进行局部区域治疗的指征:间变性癌(单独或联合手术或化疗);诊断或复发时的分化型和髓样癌;无法通过其他方法治愈的淋巴结或骨转移(手术、激素、近距离放疗);脑转移;已为大家所接受。从已发表的各种临床报告来看,结果是积极的。对于乳头状癌、滤泡状癌或髓样癌手术后存在微小或宏观残留“风险”的病例,这种方法作为“辅助”手段并非为所有人所接受。从文献分析来看,即使近期有一篇关于局部控制明显增加的报道,我们也没有支持生存率提高的数据。即使根据我们的经验,我们也无法给出确切数据(乳头状癌或滤泡状癌局部控制率为78.5%,5年生存率为57%,10年生存率为36%)。这个问题只有通过随机试验才能解决,但由于需要足够数量的病例以及即使存在疾病其“自然”生存期也很长,这些困难似乎难以克服。由于与最佳局部区域治疗相关的困难(高剂量、“危险”器官临近),我们建议在有争议的病例中采取谨慎的方法。

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