Xu H D, Qiu C G, Jiang W P
Department of Cardiovascular Diseases, First Affiliated Hospital, Suzhou Medical College.
Zhonghua Nei Ke Za Zhi. 1994 Aug;33(8):519-23.
The cellular electrophysiological effects of lysosphatidylcholine (LPC) were investigated by using patch-clamp whole cell recording and conventional microelectrode technique, LPC(10 microns) suppressed the sodium, background potassium and calcium current and the effect of LPC on activity of ionic channels was nonselective. Resting potential, action potential amplitude and maximal rate of rise of phase of action potential were decreased with LPC (50 microns) perfusing. The incidence of abnormal automaticity, early after depolarization (EAD) and delayed after depolarization (DAD) was higher. It is clearly shown that LPC accumulates at early time of myocardial ischemia and thus may induce ischemic arrhythmias.
采用膜片钳全细胞记录和传统微电极技术研究了溶血磷脂酰胆碱（LPC）的细胞电生理效应。LPC（10微摩尔）抑制钠电流、背景钾电流和钙电流，且LPC对离子通道活性的影响无选择性。用LPC（50微摩尔）灌注时，静息电位、动作电位幅度和动作电位上升相的最大速率降低。异常自律性、早期后去极化（EAD）和延迟后去极化（DAD）的发生率更高。结果清楚表明，LPC在心肌缺血早期积聚，因此可能诱发缺血性心律失常。
