Aus G, Bergdahl S, Hugosson J, Lodding P, Norlén L
Urology Division, Ostra Hospital, University of Gothenburg, Sweden.
Scand J Urol Nephrol. 1994 Dec;28(4):379-84. doi: 10.3109/00365599409180517.
Prostate specific antigen (PSA) and PSA-density (PSAd) were studied in 120 symptomatic patients with benign prostatic hyperplasia at digital rectal examination. PSA and PSAd were measured before and 3 months after transurethral resection. Comparisons were made between patients in whom histologic examination showed benign hyperplasia and those with histologically demonstrated prostatic cancer. The influence of age and of serum testosterone on PSA and PSAd was determined. PSAd in benign prostatic hyperplasia was the same in the transition zone (the adenomas) and the peripheral zone (mean 0.065), indicating no increased synthesis or leakage of PSA. PSAd with cut-off value 0.10 ng x ml-1 x cc-1 showed higher sensitivity and positive predictive value (75% vs 50% and 0.33 vs 0.15, respectively) in nonpalpable prostatic cancer than did PSA with cut-off at 4 ng x ml-1. No statistically significant influence of testosterone and/or age on serum-PSA or PSAd was found.
对120例因良性前列腺增生而出现症状且经直肠指检的患者进行了前列腺特异性抗原（PSA）和PSA密度（PSAd）的研究。在经尿道前列腺切除术前及术后3个月测量PSA和PSAd。对组织学检查显示为良性增生的患者与组织学证实为前列腺癌的患者进行了比较。确定了年龄和血清睾酮对PSA和PSAd的影响。在移行区（腺瘤）和外周区，良性前列腺增生患者的PSAd相同（平均为0.065），表明PSA的合成或渗漏没有增加。与PSA临界值为4 ng/ml相比，PSAd临界值为0.10 ng·ml-1·cc-1时，在不可触及的前列腺癌中显示出更高的敏感性和阳性预测值（分别为75%对50%和0.33对0.15）。未发现睾酮和/或年龄对血清PSA或PSAd有统计学上的显著影响。
