Roth J
Departement Pathologie, Universität Zürich, Schweiz.
Verh Dtsch Ges Pathol. 1994;78:22-5.
Cell adhesion molecules are of pivotal importance during organogenesis and fulfil important functions in maintaining normal organ architecture in the adult. Furthermore, they are involved in diverse and specialized functions such as migration and activation of leukocytes in immunosurveillance and inflammation, and homophilic as well as heterophilic interactions of cells with others and the extracellular matrix. In tumors, various cell adhesion molecules play a role in the complex process of tumor dissemination including metastatic spread. In addition, immunohistochemical detection of certain cell adhesion molecules in tumors has been shown to be of value in predicting the clinical course of the tumor disease. This short review focuses on the polysialic acid of the neural cell adhesion molecule NCAM, integrins and CD44.
细胞黏附分子在器官发生过程中至关重要，并且在维持成体正常器官结构方面发挥重要作用。此外，它们还参与多种特殊功能，如免疫监视和炎症中白细胞的迁移与激活，以及细胞与其他细胞和细胞外基质的同嗜性和异嗜性相互作用。在肿瘤中，各种细胞黏附分子在肿瘤播散（包括转移扩散）的复杂过程中发挥作用。此外，已证明肿瘤中某些细胞黏附分子的免疫组化检测在预测肿瘤疾病的临床进程方面具有价值。本简短综述聚焦于神经细胞黏附分子NCAM的多唾液酸、整合素和CD44。
