[正常及肿瘤性光暴露表皮中p53蛋白表达升高]

[Elevated p53 protein expression in normal and neoplastic light-exposed epidermis].

作者信息

Sutter C, Wersin R, Varnai M, Friemann J

机构信息

Abteilung für Umweltpathologie, Heinrich-Heine-Universität Düsseldorf.

出版信息

Verh Dtsch Ges Pathol. 1994;78:246-51.

PMID:7533993

Abstract

p53 protein levels are frequently elevated in basal (BCC) and squamous (SCC) cell carcinomas of UV-exposed sites. As recent findings in benign epidermal neoplasia (BEN) and normal epidermis (NE) are controversial, our aim was to look by immunohistochemistry for elevated p53 levels in NE (n = 52), reactive hyperplastic epidermis (REH, n = 8), BEN (n = 48), actinic keratosis (AK, n = 60), SCC (n = 13), and BCC (n = 42) of sun-exposed sites. 81.7% of AK, 100% of SCC, 73.8% of BCC as well as 29.2% of BEN, 37.5% of REH, and 26.9% of NE showed p53 positivity. The results further support that p53 elevated levels are an early marker of UV-mediated epidermal DNA damage.

摘要

在紫外线暴露部位的基底细胞癌（BCC）和鳞状细胞癌（SCC）中，p53蛋白水平常常升高。由于近期在良性表皮肿瘤（BEN）和正常表皮（NE）中的研究结果存在争议，我们的目的是通过免疫组织化学方法检测紫外线暴露部位的正常表皮（n = 52）、反应性增生性表皮（REH，n = 8）、良性表皮肿瘤（n = 48）、光化性角化病（AK，n = 60）、鳞状细胞癌（n = 13）和基底细胞癌（n = 42）中p53水平的升高情况。81.7%的光化性角化病、100%的鳞状细胞癌、73.8%的基底细胞癌以及29.2%的良性表皮肿瘤、37.5%的反应性增生性表皮和26.9%的正常表皮显示p53阳性。这些结果进一步支持p53水平升高是紫外线介导的表皮DNA损伤的早期标志物。