Bridge J A, DeBoer J, Walker C W, Neff J R
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-5440.
Genes Chromosomes Cancer. 1995 Jan;12(1):70-2. doi: 10.1002/gcc.2870120113.
Parosteal lipoma is a rare primary benign bone tumor demonstrating histopathologic features similar to those seen in the commonly occurring lipoma of soft tissue. Cytogenetic studies of soft tissue lipoma have demonstrated frequent abnormalities of 12q13-15. To the best of our knowledge the cytogenetic findings in parosteal lipoma have not yet been described. Cytogenetic analysis of a parosteal lipoma of the femur of a 51-year-old female revealed a t(3;12)(q28;q14), indicating that bone and soft tissue lipomas are cytogenetically similar and likely share a common histopathogenesis.
骨旁脂肪瘤是一种罕见的原发性良性骨肿瘤，其组织病理学特征与常见的软组织脂肪瘤相似。软组织脂肪瘤的细胞遗传学研究表明，12q13 - 15频繁出现异常。据我们所知，骨旁脂肪瘤的细胞遗传学发现尚未见报道。对一名51岁女性股骨的骨旁脂肪瘤进行细胞遗传学分析，发现了t(3;12)(q28;q14)，这表明骨脂肪瘤和软组织脂肪瘤在细胞遗传学上相似，可能具有共同的组织发病机制。
