Blackbourn D J, Chuang L F, Killam K F, Chuang R Y
Department of Medical Pharmacology and Toxicology, School of Medicine, University of California, Davis 95616.
J Med Primatol. 1994 Aug;23(6):343-54. doi: 10.1111/j.1600-0684.1994.tb00297.x.
The ability of the CD8+ cells from simian immunodeficiency virus (SIV)-infected rhesus macaques to inhibit SIV replication was investigated. Inhibition was produced by a heat-stable soluble factor of molecular size greater than 10kDa. CD8+ supernatants from some macaques were found not only to suppress SIV growth but also to be cytolytic toward both infected and uninfected CD4+ cells. Such indiscriminate CD8+ cell-mediated cell killing may therefore account for DC4+ cell depletion in certain SIV-infected macaques.
