Ishibashi K, Sasaki S
Renal Unit, Oome General Hospital.
Nihon Rinsho. 1995 Jan;53(1):250-7.
17 members of MIP family from bacteria, yeast, plants and animals are compared in this review. These proteins appear to function in (1) water channels (CHIP, WCH-CD, MIWC, AQP3, gTIP, RD28, TobRB7), (2) neurogenesis (Bib), (3) small-molecule-permeating channels (MIP, AQP3, NOD, Glpf), (4) unknown function (WCH-3, AtRB7, Pea R7A, FPS1). However, the biological functions are not well established. The most conserved residues in the first and the second halves of all MIP family proteins are asparagine-proline-alanine (NPA) sequences in the loops (NPA boxes). This structural similarity may lead to functional similarity (water and/or small molecule permeation). This signature sequence for the MIP family will facilitate the identification of new protein members of this family.
本综述比较了来自细菌、酵母、植物和动物的17种MIP家族成员。这些蛋白质似乎在以下方面发挥作用：（1）水通道（CHIP、WCH-CD、MIWC、AQP3、gTIP、RD28、TobRB7），（2）神经发生（Bib），（3）小分子通透通道（MIP、AQP3、NOD、Glpf），（4）功能未知（WCH-3、AtRB7、豌豆R7A、FPS1）。然而，其生物学功能尚未完全明确。所有MIP家族蛋白前半段和后半段中最保守的残基是环中的天冬酰胺-脯氨酸-丙氨酸（NPA）序列（NPA框）。这种结构相似性可能导致功能相似（水和/或小分子通透）。MIP家族的这种特征序列将有助于鉴定该家族新的蛋白质成员。
