在慢性复发性多神经病中与多种神经节苷脂反应的单克隆IgM
Monoclonal IgM reactive with several gangliosides in a chronic relapsing polyneuropathy.
作者信息
Brindel I, Preud'homme J L, Vallat J M, Vincent D, Vasquez J L, Jauberteau M O
机构信息
Laboratories of Immunology, Limoges University Hospital, France.
出版信息
Neurosci Lett. 1994 Nov 7;181(1-2):103-6. doi: 10.1016/0304-3940(94)90570-3.
PMID:7534889
Abstract
A possibly pathogenic serum monoclonal IgM lambda from a patient with chronic relapsing polyneuropathy was shown to react with the disialosyl-lactosyl residue (NeuAc alpha 2-8NeuAc alpha 2-3) -Gal beta 1-4Glc expressed by GD1b, GT1b, GQ1b, GD2 and GD3. A part of this epitope in terminal position in GM3, GD1a and LM1 was also recognized by the IgM lambda.
摘要
一名患有慢性复发性多神经病患者的一种可能具有致病性的血清单克隆IgM λ被证明可与由GD1b、GT1b、GQ1b、GD2和GD3表达的二唾液酸乳糖基残基（NeuAcα2-8NeuAcα2-3）-Galβ1-4Glc发生反应。GM3、GD1a和LM1中位于末端位置的该表位的一部分也被IgM λ识别。
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