Phelps R G, Klauer J, Wolfe D, Cernainu G
Department of Dermatology, Mt. Sinai School of Medicine, New York, New York.
Am J Dermatopathol. 1995 Feb;17(1):42-7. doi: 10.1097/00000372-199502000-00008.
We studied 11 cases of mixed tumor of the skin with a polyclonal antibody against human type II collagen. Two of the cases were of the eccrine type, six were apocine, and three were malignant. In all of the benign cases of mixed tumor and in some of the malignant type, "chondroid" and mucinous portions stained. The clearly epithelial portions of the tumor stained as well, and staining was most intense in the eccrine types and least intense in the malignant types. The positive staining in mixed tumors may help elucidate the histogenesis of these unusual tumors as well as help differentiate among the various subtypes.
我们使用抗人II型胶原蛋白的多克隆抗体研究了11例皮肤混合瘤。其中2例为小汗腺型，6例为大汗腺型，3例为恶性。在所有良性混合瘤病例以及部分恶性类型中，“软骨样”和黏液部分呈染色阳性。肿瘤明显的上皮部分也呈染色阳性，且在小汗腺型中染色最为强烈，在恶性类型中染色最浅。混合瘤中的阳性染色可能有助于阐明这些不寻常肿瘤的组织发生，以及有助于区分各种亚型。
