[母体血清甲胎蛋白作为胎儿唐氏综合征的筛查试验]
[Maternal serum alpha-fetoprotein as a screening test for fetal Down syndrome].
作者信息
Bessho T, Kanazawa R, Shiotani T, Mitsuo M, Koyama K
机构信息
Perinatal Unit, Hyogo Medical College.
出版信息
Nihon Sanka Fujinka Gakkai Zasshi. 1995 Mar;47(3):237-43.
An association between a low maternal serum alpha-fetoprotein (MSAFP) level and an increased incidence of Down syndrome is well documented. This study was undertaken to elucidate the diagnostic efficacy of MSAFP as a screening test for Down syndrome in 711 Japanese women who underwent genetic amniocentesis between 14 and 20 gestational weeks of age in Hyogo Medical College Hospital. The mean value for the multiple of the median (MoM) of the MSAFP level in 11 pregnancies associated with Down syndrome was 0.78 +/- 0.47 and 1.12 +/- 0.67, respectively. A cut-off value of < 0.45, < 0.50, < 0.55 and < 0.60 MoM yielded negative predictive values of 98.6%, 98.5%, 99.0% and 99.2%, positive predictive values of 6.3%, 4.0%, 9.1% and 8.6%, a sensitivity of 9.1%, 9.1%, 36.4% and 54.5%, and false positive rates of 2.1%, 3.4%, 5.7% and 9.1%, respectively. The combining of MSAFP and maternal age improves the expected results of a strategy for Down syndrome.
孕妇血清甲胎蛋白（MSAFP）水平偏低与唐氏综合征发病率增加之间的关联已有充分记录。本研究旨在阐明在兵库医科大学医院14至20孕周接受遗传羊膜穿刺术的711名日本女性中，MSAFP作为唐氏综合征筛查试验的诊断效力。11例与唐氏综合征相关的妊娠中，MSAFP水平中位数倍数（MoM）的平均值分别为0.78±0.47和1.12±0.67。MoM值<0.45、<0.50、<0.55和<0.60时，阴性预测值分别为98.6%、98.5%、99.0%和99.2%，阳性预测值分别为6.3%、4.0%、9.1%和8.6%，灵敏度分别为9.1%、9.1%、36.4%和54.5%，假阳性率分别为2.1%、3.4%、5.7%和9.1%。将MSAFP与孕妇年龄相结合可改善唐氏综合征筛查策略的预期结果。
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