Heales S J, Bolaños J P, Land J M, Clark J B
Department of Neurochemistry, Institute of Neurology, London, UK.
Brain Res. 1994 Dec 30;668(1-2):243-5. doi: 10.1016/0006-8993(94)90530-4.
The efficacy of cystine, ascorbate and trolox, a vitamin E analogue, at protecting against nitric oxide-mediated mitochondrial complex IV damage has been investigated in cultured astrocytes. Of these compounds, only trolox afforded protection. It is suggested that lipid peroxidation is responsible for nitric oxide-mediated mitochondrial damage and that inhibitors of this process may be of therapeutic benefit in conditions where excessive nitric oxide production is implicated.
已在培养的星形胶质细胞中研究了胱氨酸、抗坏血酸盐和维生素E类似物生育三烯酚在保护免受一氧化氮介导的线粒体复合物IV损伤方面的功效。在这些化合物中，只有生育三烯酚具有保护作用。有人提出，脂质过氧化是一氧化氮介导的线粒体损伤的原因，并且该过程的抑制剂在涉及一氧化氮产生过多的病症中可能具有治疗益处。
