Kabuto H, Yokoi I, Endo A, Takei M, Kurimoto T, Mori A
Department of Neuroscience, Okayama University Medical School, Japan.
Acta Med Okayama. 1994 Dec;48(6):311-6. doi: 10.18926/AMO/31102.
Serotonin (5-HT) is thought to play an important role in the seizures of El mice because the seizure threshold of El mice correlates with the 5-HT concentration in the central nervous system. In this study, the anticonvulsant effect of a 5-HT reuptake blocker, citalopram, was evaluated behaviorally and biochemically. El mouse convulsions were inhibited by chronic administration of citalopram (80 mg/kg/day, p.o. for 2 weeks), but were not inhibited by acute administration of citalopram (80 mg/kg, i.p., 2 h after single injection). Both chronic and acute administration of citalopram decreased the concentration of 5-hydroxyindolacetic acid in the brain, whereas the concentration of 5-HT was not changed by treatment with citalopram. Tryptophan hydroxylase activity was not different between the citalopram and control groups, although the monoamine oxydase-A activity was lowered by chronic administration of citalopram. These findings suggest that both acute and chronic administration of citalopram depresses the 5-HT turnover rate, however chronic administration is necessary to inhibit El mouse convulsions.
血清素（5-羟色胺，5-HT）被认为在El小鼠的癫痫发作中起重要作用，因为El小鼠的癫痫发作阈值与中枢神经系统中的5-HT浓度相关。在本研究中，对5-HT再摄取阻滞剂西酞普兰的抗惊厥作用进行了行为学和生物化学评估。慢性给予西酞普兰（80毫克/千克/天，口服，持续2周）可抑制El小鼠惊厥，但急性给予西酞普兰（80毫克/千克，腹腔注射，单次注射后2小时）则无抑制作用。西酞普兰的慢性和急性给药均降低了脑中5-羟吲哚乙酸的浓度，而西酞普兰治疗并未改变5-HT的浓度。尽管慢性给予西酞普兰可降低单胺氧化酶-A的活性，但西酞普兰组和对照组之间的色氨酸羟化酶活性并无差异。这些发现表明，西酞普兰的急性和慢性给药均会降低5-HT的周转率，然而，抑制El小鼠惊厥需要慢性给药。
