正常及帕金森病壳核中含NADPH-黄递酶/一氧化氮合酶的神经元

NADPH-diaphorase/nitric oxide synthase containing neurons in normal and Parkinson's disease putamen.

作者信息

Böckelmann R, Wolf G, Ransmayr G, Riederer P

机构信息

Institute of Medical Neurobiology, Medical Faculty, University of Magdeburg, Federal Republic of Germany.

出版信息

J Neural Transm Park Dis Dement Sect. 1994;7(2):115-21. doi: 10.1007/BF02260966.

DOI:10.1007/BF02260966

PMID:7536004

Abstract

Nitric oxide (NO) is thought to be involved in neurodegenerative processes. Concerning Parkinson's disease (PD) it remains to be elucidated, if NO contributes to pathological alterations in the striatum. The present study evaluates the post-mortem putamen of PD patients and control subjects for distribution patterns of NO-synthase containing neurons, using the NADPH-diaphorase technique. The ratio of positively stained neurons and the total number of cells (control: 1,120 +/- 69 per mm2, n = 5; PD: 575 +/- 164mm2, n = 5) shows striking differences between controls and PD patients. Our findings give reason to conclude that NADPH-diaphorase positive structures may have pathogenetic importance in degenerative processes in PD putamen.

摘要

一氧化氮（NO）被认为与神经退行性过程有关。关于帕金森病（PD），NO是否导致纹状体的病理改变仍有待阐明。本研究采用NADPH黄递酶技术，评估PD患者和对照受试者的尸检壳核中含一氧化氮合酶神经元的分布模式。阳性染色神经元与细胞总数的比例（对照：每平方毫米1120±69个，n = 5；PD：每平方毫米575±164个，n = 5）显示，对照与PD患者之间存在显著差异。我们的研究结果表明，NADPH黄递酶阳性结构可能在PD壳核的退行性过程中具有致病重要性。