Self-determinants in autoimmune demyelinating disease: changes in T- cell response specificity.
作者信息
Tuohy V K, Fritz R B, Ben-Nun A
机构信息
Cleveland Clinic Foundation, Department of Immunology, OH 44195.
出版信息
Curr Opin Immunol. 1994 Dec;6(6):887-91. doi: 10.1016/0952-7915(94)90009-4.
PMID:7536010
Abstract
Recent research developments support the following views regarding antigen recognition in autoimmune demyelinating disease: there may be no single autoimmune target protein; diverse peptide self-determinants from multiple myelin proteins can be recognized; target determinant epitopes may differ among individuals; and target epitope recognition can change with time during the course of disease.
摘要
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