The distinction blurs between an autoimmune versus microbial hypothesis in multiple sclerosis.
作者信息
Hafler D A
机构信息
Harvard Medical School and Brigham and Women's Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
出版信息
J Clin Invest. 1999 Sep;104(5):527-9. doi: 10.1172/JCI8193.
Abstract
摘要
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本文引用的文献
1
Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler's virus-infected mice.在感染泰勒氏病毒的小鼠中，中枢神经系统驻留抗原呈递细胞对内源性自身髓磷脂表位的呈递。
J Clin Invest. 1999 Sep;104(5):599-610. doi: 10.1172/JCI7292.
2
3
Immunopathology of multiple sclerosis: report on an international meeting held at the Institute of Neurology of the University of Vienna.多发性硬化症的免疫病理学：关于在维也纳大学神经病学研究所召开的一次国际会议的报告
J Neuroimmunol. 1998 Jun 15;86(2):213-7. doi: 10.1016/s0165-5728(98)00031-9.
4
Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation.自身反应性T细胞在多发性硬化症中的扩增独立于外源性B7共刺激。
J Immunol. 1998 Feb 1;160(3):1532-8.
5
Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading.泰勒氏病毒的持续感染通过表位扩展导致中枢神经系统自身免疫。
Nat Med. 1997 Oct;3(10):1133-6. doi: 10.1038/nm1097-1133.
6
Direct ex vivo analysis of activated, Fas-sensitive autoreactive T cells in human autoimmune disease.对人类自身免疫性疾病中活化的、Fas敏感的自身反应性T细胞进行直接离体分析。
J Exp Med. 1997 May 5;185(9):1585-94. doi: 10.1084/jem.185.9.1585.
7
Distinct patterns of multiple sclerosis pathology indicates heterogeneity on pathogenesis.多发性硬化症病理学的不同模式表明其发病机制存在异质性。
Brain Pathol. 1996 Jul;6(3):259-74. doi: 10.1111/j.1750-3639.1996.tb00854.x.
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N Engl J Med. 1993 Apr 22;328(16):1173-82. doi: 10.1056/NEJM199304223281608.
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