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The stability of bacterial vaccines at elevated temperatures.

作者信息

Stainer D W, Hart F E

出版信息

Dev Biol Stand. 1978;41:249-53.

PMID:753653
Abstract

The requirements for vaccines demand that they be safe and efficacious. The recommended storage temperature for vaccines is 2-8 degrees C, but their conditions of storage and transportation in the developing countries may frequently be far from ideal. This had led to the present study in which several vaccines have been stored at ambient temperature (+24 degrees C) and at +37 degrees C and their antigenic stabilities examined. Under these adverse conditions, typhoid, cholera and the components of DPT vaccines either in final containers or in bulk form have been shown to be stable for extended periods of time.

摘要

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Factors affecting the immunogenicity and potency of tetanus toxoid: implications for the elimination of neonatal and non-neonatal tetanus as public health problems.影响破伤风类毒素免疫原性和效力的因素:对消除新生儿和非新生儿破伤风这一公共卫生问题的启示
Bull World Health Organ. 1997;75(1):81-93.