Savchenko O N, Proĭmina F I, Rakitskaia V V, Flerova N I
Fiziol Zh Im I M Sechenova. 1994 Nov;80(11):57-63.
Neonatal administration of hydrocortisone decrease steroidogenesis in the rat adrenals in immature and mature animals production of progesterone and androstenedione reducing, at that. Primary long-term disturbance of central regulatory influences controlling steroidogenesis in adrenals, was proposed. The steroid production disturbance in the gonads was lesser than in the adrenals and was found only in mature rats.
新生大鼠给予氢化可的松会降低未成熟和成熟动物肾上腺中类固醇生成,同时减少孕酮和雄烯二酮的产生。据此提出,存在对肾上腺类固醇生成的中枢调节影响的原发性长期干扰。性腺中的类固醇生成干扰比肾上腺中的小,且仅在成熟大鼠中发现。