Jimenez F, Clark R E, Buchanan M D, Kamino H
Division of Dermatology, Duke University Medical Center, Durham, North Carolina, USA.
J Am Acad Dermatol. 1995 May;32(5 Pt 2):878-81. doi: 10.1016/0190-9622(95)91552-4.
Lymphoepithelioma-like carcinoma of the skin (LLCS) is a rare cutaneous neoplasm that histologically resembles nasopharyngeal lymphoepithelioma. Conventional surgical excision carries a considerable rate of recurrence (three of 11 reported cases with such treatment, with one patient dying of metastatic disease). We report the first case of lymphoepithelioma-like carcinoma of the skin treated with Mohs micrographic surgery. Because of its tendency to occur on the face and its potential for recurrence after incomplete removal, this tumor is a good candidate for treatment with Mohs micrographic surgery. Immunohistochemical staining of frozen sections for cytokeratins may help to detect neoplastic cells that may be obscured by the dense lymphoplasmacytic infiltrate associated with this tumor.
皮肤淋巴上皮瘤样癌（LLCS）是一种罕见的皮肤肿瘤，组织学上类似于鼻咽淋巴上皮瘤。传统手术切除术后复发率相当高（11例接受此类治疗的报告病例中有3例复发，其中1例患者死于转移性疾病）。我们报告首例采用莫氏显微外科手术治疗的皮肤淋巴上皮瘤样癌病例。由于该肿瘤倾向于发生在面部且不完全切除后有复发的可能，因此是莫氏显微外科手术治疗的理想对象。对冰冻切片进行细胞角蛋白免疫组化染色可能有助于检测被与该肿瘤相关的密集淋巴浆细胞浸润所掩盖的肿瘤细胞。
