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[血液吸附对大肠炎症性疾病患者血清糖蛋白浓度的影响]

[The effect of hemosorption on the glycoprotein concentration of the blood serum in inflammatory diseases of the large intestine].

作者信息

Ivanov A F, Eroshkina T D, Fomin S A, Musin I I, Chirkin V V

出版信息

Ter Arkh. 1995;67(2):36-9.

PMID:7536960
Abstract

71 patients with nonspecific diseases of the colon were examined before and after hemosorption for concentrations of seromucoid, orosomucoid, immunoglobulins G,M,A, C3 and C4 complement component fractions, haptoglobin, ceruloplasmin, alpha 1-antitrypsin, C-reactive protein, properdin, transferrin. It was found that hemosorption results in lowering of all the above concentrations in nonspecific ulcerative colitis, except seromucoid and orosomucoid in moderate and acute colitis. In response to hemosorption serum glycoproteins levels varied with the disease severity, its duration and metabolic activity of the liver. Concentrations of seromucoids, orosomucoid, alpha 1-antitrypsin changed in correlation with clinical manifestations of colon inflammation and may serve as criteria of hemosorption efficacy.

摘要

对71例患有结肠非特异性疾病的患者在血液吸附前后进行了血清类黏蛋白、血清类黏蛋白原、免疫球蛋白G、M、A、C3和C4补体成分、触珠蛋白、铜蓝蛋白、α1-抗胰蛋白酶、C反应蛋白、备解素、转铁蛋白浓度的检测。结果发现,除中度和急性结肠炎中的血清类黏蛋白和血清类黏蛋白原外,血液吸附可使非特异性溃疡性结肠炎患者上述所有物质的浓度降低。血清糖蛋白水平因血液吸附而发生变化,其变化与疾病严重程度、病程以及肝脏代谢活性有关。血清类黏蛋白、血清类黏蛋白原、α1-抗胰蛋白酶的浓度变化与结肠炎症的临床表现相关,可作为血液吸附疗效的标准。

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