Long-term effect of perinatal neurochemical lesions of brain monoaminergic neurons on body growth, growth hormone secretion and thyroid activity.

In the present experiments, extended studies were performed on long-term effect of perinatal neurotoxic damage of brain monoaminergic neurons exerted on Grown Hormone (GH) and on Thyrotrophic Hormone (TSH) secretion. Neurotoxins were applied for selective destruction of the different components of the monoaminergic neuron system. Deficient GH secretion and reduced TSH-mobilizing capacity were observed in consequence of perinatal injury of dopaminergic neurons, meanwhile in perinatal serotonergic lesion bearing rats, reduced GH secretion was associated with increased reactivity of the TSH-mobilizing mechanism. The results show that perinatal damage of monoaminergic neurons induce long-lasting alteration of the neural mechanisms regulating GH and TSH secretion.