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[胃黏膜的细胞与分子机制:黏膜损伤及抗酸剂的保护作用]

[Cellular and molecular mechanisms of the gastric mucosa: injury of the mucosa and the protective action of antacids].

作者信息

Tarnawski A

机构信息

Universidad de California, Irvine.

出版信息

Rev Gastroenterol Peru. 1995 Jan-Apr;15(1):74-8.

PMID:7537548
Abstract

Gastrointestinal mucosa is exposed to many substances, some made by their own body as HCl, pepsin, etc, others from exogenous origin as NSAIDs, alcohol etc. that injury the mucosa. The body has build protective mechanism against the injury that we describe in the article. We know antacids acts neutralizing the acid a now we know it work as a powerful stimulant of the mucosal protection. This is called cytoprotection and is described in the article.

摘要

胃肠道黏膜会接触到许多物质,一些是由自身机体产生的,如盐酸、胃蛋白酶等,另一些则来自外部,如非甾体抗炎药、酒精等,这些物质会损伤黏膜。机体已经建立了针对这种损伤的保护机制,我们将在本文中进行描述。我们知道抗酸剂通过中和胃酸发挥作用,现在我们还知道它作为黏膜保护的强大刺激剂发挥作用。这被称为细胞保护作用,本文将对此进行描述。

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