妊娠次数对游离β-人绒毛膜促性腺激素唐氏综合征筛查的影响。
The influence of gravidity on Down's syndrome screening with free beta hCG.
作者信息
Spencer K
机构信息
Clinical Biochemistry Department, Oldchurch Hospital, Romford, Essex, U.K.
出版信息
Prenat Diagn. 1995 Jan;15(1):87-9. doi: 10.1002/pd.1970150119.
PMID:7537879
Abstract
Total human chorionic gonadotropin (hCG) levels have been shown in one previous small study to vary with gravidity. In order to establish if maternal serum free beta hCG was similarly affected, approximately 4500 pregnancies of varying gravidity were analysed. The results indicated that there was a 6 per cent higher median MOM in primigravid compared with multigravid women. The impact of such elevation in Down's syndrome screening programmes will be minimal.
摘要
在之前一项小型研究中已表明，人绒毛膜促性腺激素（hCG）的总水平会随妊娠次数而变化。为了确定孕妇血清游离β-hCG是否同样受到影响，对约4500例不同妊娠次数的孕妇进行了分析。结果表明，初产妇的中位倍数（MOM）比经产妇高6%。这种升高在唐氏综合征筛查项目中的影响将是最小的。
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