Williams G H, Williams E D
Department of Pathology, Cambridge University, Addenbrookes Hospital, U.K.
J Pathol. 1995 Mar;175(3):279-81. doi: 10.1002/path.1711750305.
A reverse transcriptase nested polymerase reaction (RT-nPCR) method has been developed to detect the presence of a tumour-specific translocation in archival formalin-fixed, paraffin-embedded tissue. This technique can be applied to the large numbers of tumours in pathology departments' archives, allowing correlation of translocations with morphological diagnosis, response to therapy, and survival.
