Froon A H, Dentener M A, Greve J W, Ramsay G, Buurman W A
Department of Surgery, University Hospital Maastricht, University of Limburg, Netherlands.
J Infect Dis. 1995 May;171(5):1250-7. doi: 10.1093/infdis/171.5.1250.
The toxicity of lipopolysaccharide (LPS) is modified by several proteins, such as bactericidal/permeability-increasing protein (BPI) and LPS-binding protein (LBP). BPI and LBP plasma levels were measured in patients with gram-negative (n = 36) or gram-positive (n = 28) bacteremia. Levels of BPI and LBP, which are proteins that neutralize and enhance LPS effects, respectively, were increased before bacteremia was first detected. The BPI/neutrophil ratio, reflecting neutrophil activation, was significantly associated with the presence of sepsis syndrome and death in bacteremic patients: 1.06 (0.11-6.49) versus 0.57 (0.06-3.82) in patients with and without sepsis syndrome (P < .01), respectively, and 0.64 (0.06-3.82) versus 1.02 (0.12-6.49) in survivors and nonsurvivors (P < .05), respectively (ratio in nanograms of BPI per 10(6) neutrophils). High LBP peak levels were significantly associated with the presence of sepsis syndrome (P < .01). No differences in BPI and LBP levels were observed in patients with gram-negative versus gram-positive bacteremia. BPI/neutrophil ratio, as a parameter of neutrophil activation, may be useful in monitoring infectious disease.
脂多糖（LPS）的毒性会受到多种蛋白质的影响，如杀菌/通透性增加蛋白（BPI）和LPS结合蛋白（LBP）。对革兰氏阴性菌血症患者（n = 36）和革兰氏阳性菌血症患者（n = 28）测定了BPI和LBP的血浆水平。分别具有中和LPS作用和增强LPS作用的BPI和LBP水平，在首次检测到菌血症之前就已升高。反映中性粒细胞活化的BPI/中性粒细胞比值，与菌血症患者发生脓毒症综合征和死亡显著相关：有脓毒症综合征的患者为1.06（0.11 - 6.49），无脓毒症综合征的患者为0.57（0.06 - 3.82）（P <.01）；幸存者为0.64（0.06 - 3.82），非幸存者为1.02（0.12 - 6.49）（P <.05）（比值为每10⁶个中性粒细胞中BPI的纳克数）。高LBP峰值水平与脓毒症综合征的存在显著相关（P <.01）。革兰氏阴性菌血症患者和革兰氏阳性菌血症患者的BPI和LBP水平未观察到差异。BPI/中性粒细胞比值作为中性粒细胞活化的一个参数，可能有助于监测传染病。
