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[Memotherm支架治疗良性前列腺增生的初步经验]

[Initial experiences with the Memotherm Stent in treatment of benign prostatic hyperplasia].

作者信息

Gottfried H W, Schimers H P, Gschwend J, Brändle E, Hautmann R

机构信息

Urologische Universitätsklinik Ulm.

出版信息

Urologe A. 1995 Mar;34(2):110-8.

PMID:7538708
Abstract

We report our experience with a new thermosensitive stent (Memotherm), which has been invented recently as an alternative method for treatment of benign prostatic hyperplasia. The wall of this stent is a thermoreactive mesh made of nitinol, which reaches its maximum force of expansion at body temperature. Its high degree of flexibility allows the Memotherm stent to fit the natural course of the prostatic urethra. This stent is available in different sizes between 2 and 8 cm to meet the demand for different lengths of prostatic urethra. Furthermore, the meshed structure of this stent allows its atraumatic removal. From April 1992 to September 1993, 54 consecutive patients with benign prostatic hyperplasia and Memotherm stents inserted. The mean patient age was 76.1 years (range 61-98 years). Patients were considered suitable for treatment with the Memotherm stent when they presented with a poor operative risk. Mean prostatic volume was 51.9 +/- 25 ml (20-150 ml), and on average a stent measured 32.3 +/- 9.5 mm (20-70 mm). Preoperatively, only 14 patients (26%) were able to void, and 40 patients (74%) had had a transurethral or suprapubic catheter placed. After placement of the Memotherm stent, 53 of 54 patients were able to void. In the patients who were able to void preoperatively, the mean maximum flow rate increased from 4.5 ml/s to 15.8 ml/s within the first 6 months after treatment. Within the same period of time, the mean residual urine volume decreased from 194.4 ml to 11.8 ml, and the AUA 6-Symptom Score improved from 24 to 3.5 points. All differences are statistically significant (P < 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

我们报告了使用一种新型热敏支架(Memotherm)的经验,该支架是最近发明的一种治疗良性前列腺增生的替代方法。这种支架的壁是由镍钛合金制成的热反应性网,在体温下达到其最大扩张力。其高度的柔韧性使Memotherm支架能够贴合前列腺尿道的自然走向。该支架有2至8厘米的不同尺寸可供选择,以满足不同长度前列腺尿道的需求。此外,这种支架的网状结构使其能够无创伤地取出。从1992年4月至1993年9月,连续54例良性前列腺增生患者植入了Memotherm支架。患者的平均年龄为76.1岁(范围61 - 98岁)。当患者手术风险较差时,被认为适合使用Memotherm支架治疗。平均前列腺体积为51.9±25毫升(20 - 150毫升),平均支架尺寸为32.3±9.5毫米(20 - 70毫米)。术前,只有14例患者(26%)能够排尿,40例患者(74%)已放置经尿道或耻骨上导管。植入Memotherm支架后,54例患者中有53例能够排尿。术前能够排尿的患者,治疗后的前6个月内平均最大尿流率从4.5毫升/秒增加到15.8毫升/秒。在同一时期,平均残余尿量从194.4毫升减少到11.8毫升,美国泌尿外科学会6症状评分从24分提高到3.5分。所有差异均具有统计学意义(P < 0.02)。(摘要截断于250字)

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