Debiec-Rychter M, Lasota J, Alwasiak J, Liberski P P
Department of Oncology, Medical Academy of Lodz, Poland.
Acta Neuropathol. 1995;89(3):270-4. doi: 10.1007/BF00309343.
Cytogenetic analysis on a supratentorial, recurrent, anaplastic ependymoma from a 29-year-old female disclosed the presence of an abnormal clone with the karyotype 46,XX,der(8)t(8;11)(q24;p11),-11,add(?)t(?;11)(?;q13). By the Northern hybridization assay and immunohistochemical staining, tumor cells revealed overexpression of c-myc proto-oncogene, although no evidence of amplification or structural rearrangement of this gene was found.
对一名29岁女性的幕上复发性间变性室管膜瘤进行细胞遗传学分析，发现存在一个异常克隆，其核型为46,XX,der(8)t(8;11)(q24;p11),-11,add(?)t(?;11)(?;q13)。通过Northern杂交分析和免疫组织化学染色，肿瘤细胞显示c-myc原癌基因过表达，尽管未发现该基因扩增或结构重排的证据。
