Moody W J
Department of Zoology, University of Washington, Seattle 98117, USA.
Perspect Dev Neurobiol. 1995;2(4):309-15.
The development of ion channel properties in excitable cells begins in the very early embryo and continues throughout differentiation. The pattern of ion channel development in a given cell type is not a simple linear progression to the mature state, but rather is a complex sequence of modulatory events that create windows of time during which excitability is qualitatively different from that in the mature cell. These windows are likely candidates for critical periods when electrical activity influences later development.
可兴奋细胞中离子通道特性的发展始于胚胎早期，并在整个分化过程中持续进行。特定细胞类型中离子通道的发育模式并非简单地线性发展至成熟状态，而是一系列复杂的调节事件，这些事件创造了一些时间窗口，在此期间细胞的兴奋性在质上与成熟细胞不同。这些时间窗口很可能是电活动影响后期发育的关键期的候选阶段。
