Fulton B P
Department of Anatomy and Developmental Biology, University College London, United Kingdom.
Perspect Dev Neurobiol. 1995;2(4):327-34.
Cell-cell interactions are important in the development of the nervous system. Gap junctions (GJs) form direct intercellular channels that permit diffusion of ions and small molecules and thus cells linked by GJs can influence each other's properties or behavior either through transmission of electrical signals or through transfer of signaling molecules. In the developing nervous system, widespread GJ communication occurs at the time of neural induction, but in the adult nervous system it is much more restricted. In addition, certain events in neural development appear to involve the formation of transient junctional connections. This review examines briefly four aspects of neural development in which GJs may be involved, namely, neurulation, regional differentiation, migration, and axon guidance.
细胞间相互作用在神经系统发育中很重要。缝隙连接（GJs）形成直接的细胞间通道，允许离子和小分子扩散，因此通过缝隙连接相连的细胞可以通过电信号传递或信号分子转移来相互影响彼此的特性或行为。在发育中的神经系统中，广泛的缝隙连接通讯发生在神经诱导时期，但在成体神经系统中则受到更多限制。此外，神经发育中的某些事件似乎涉及瞬时连接的形成。本综述简要探讨了缝隙连接可能参与的神经发育的四个方面，即神经胚形成、区域分化、迁移和轴突导向。
