Richmond R E, Carter J H, Carter H W, Daniel F B, DeAngelo A B
Department of Biological Sciences, Northern Kentucky University, Highland Heights 41099, USA.
Cancer Lett. 1995 May 25;92(1):67-76. doi: 10.1016/0304-3835(94)03756-9.
We examined the incidence of proliferative lesions, hyperplastic nodules and altered hepatic foci, in male F344 rat liver, to determine their preneoplastic potential during dichloroacetic acid (DCA)-induced hepatocarcinogenesis. Immunohistochemical and image analysis methods were used to detect the expression of 6 histochemical markers of neoplastic cells; p21 ras, p39 c-jun, p55 c-fos, aldehyde dehydrogenase (ALDH), glutathione s-transferase (GST-p), and alpha fetoprotein (AFP) during DCA-induced hepatocarcinogenesis. Our results were consistent with our previous data and suggested that the hyperplastic nodules, rather than altered hepatic foci, is a putative preneoplastic lesion during DCA-induced hepatocarcinogenesis in the male F344 rat.
我们研究了雄性F344大鼠肝脏中增殖性病变、增生性结节和肝灶性改变的发生率，以确定它们在二氯乙酸（DCA）诱导的肝癌发生过程中的癌前潜能。采用免疫组织化学和图像分析方法检测肿瘤细胞的6种组织化学标志物的表达；在DCA诱导的肝癌发生过程中检测p21 ras、p39 c-jun、p55 c-fos、醛脱氢酶（ALDH）、谷胱甘肽S-转移酶（GST-p）和甲胎蛋白（AFP）。我们的结果与我们之前的数据一致，并表明增生性结节而非肝灶性改变是雄性F344大鼠DCA诱导的肝癌发生过程中的一种假定癌前病变。
