Larner A C, Finbloom D S
Division of Cytokine Biology, Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA.
Biochim Biophys Acta. 1995 May 12;1266(3):278-87. doi: 10.1016/0167-4889(95)00015-k.
Two well-defined rapid responses which occur as a consequence of growth factors binding to their cell surface receptors involve tyrosine phosphorylation of cellular proteins and the induction of the transcription of cellular genes. Recent advances have been made in purification and cloning of Src homology 2 and 3 (SH2/SH3) domain-containing transcription factors which are required for the activation of early response genes by interferons. These transcription factors are covalently modified by tyrosine phosphorylation such that they interact with enhancers needed for interferon-stimulated gene expression. The Jak family of tyrosine kinases are also an integral component in these signalling cascades. The information gained concerning interferon signalling has now been extended to include a broad network of cytokine-regulated signalling systems which use tyrosine phosphorylation of a family of structurally related proteins to activate transcription of early response genes.
生长因子与细胞表面受体结合后会引发两种明确的快速反应，涉及细胞蛋白质的酪氨酸磷酸化以及细胞基因转录的诱导。在纯化和克隆含Src同源2和3（SH2/SH3）结构域的转录因子方面取得了新进展，这些转录因子是干扰素激活早期反应基因所必需的。这些转录因子通过酪氨酸磷酸化进行共价修饰，从而与干扰素刺激基因表达所需的增强子相互作用。酪氨酸激酶的Jak家族也是这些信号级联反应的一个组成部分。目前，关于干扰素信号传导所获得的信息已扩展到包括一个广泛的细胞因子调节信号系统网络，该网络利用一组结构相关蛋白质的酪氨酸磷酸化来激活早期反应基因的转录。
