Roth S, Neuman-Silberberg F S, Barcelo G, Schüpbach T
Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, New Jersey 08544, USA.
Cell. 1995 Jun 16;81(6):967-78. doi: 10.1016/0092-8674(95)90016-0.
In Drosophila, the dorsal-ventral polarity of the egg chamber depends on the localization of the oocyte nucleus and the gurken RNA to the dorsal-anterior corner of the oocyte. Gurken protein presumably acts as a ligand for the Drosophila EGF receptor (torpedo/DER) expressed in the somatic follicle cells surrounding the oocyte. cornichon is a gene required in the germline for dorsal-ventral signaling. cornichon, gurken, and torpedo also function in an earlier signaling event that establishes posterior follicle cell fates and specifies the anterior-posterior polarity of the egg chamber. Mutations in all three genes prevent the formation of a correctly polarized microtubule cytoskeleton required for proper localization of the anterior and posterior determinants bicoid and oskar and for the asymmetric positioning of the oocyte nucleus.
在果蝇中，卵室的背腹极性取决于卵母细胞核和gurken RNA在卵母细胞背前角的定位。推测Gurken蛋白作为果蝇表皮生长因子受体（鱼雷/ DER）的配体，该受体在围绕卵母细胞的体细胞滤泡细胞中表达。cornichon是生殖系中背腹信号传导所需的一个基因。cornichon、gurken和鱼雷也在一个早期信号事件中发挥作用，该事件确立了后滤泡细胞命运并确定了卵室的前后极性。这三个基因的突变会阻止形成正确极化的微管细胞骨架，而这种骨架对于前后决定因子bicoid和oskar的正确定位以及卵母细胞核的不对称定位是必需的。
