Nakajima T, Noguchi T, Kumahara Y, Sugihara A, Yamazaki T, Iwasaki T, Hamano T, Kakishita E
Japan Research Foundation for Chronic Diseases and Rehabilitation Affilated Hospital, Sakuragaoka Hospital.
Rinsho Ketsueki. 1995 Apr;36(4):359-64.
A 68-year-old man who was admitted to our hospital because of general fatigue and anorexia. He was diagnosed as suffering from neuron specific enolase (NSE)-producing IgD-lambda type multiple myeloma with high activity of serum amylase, based on the detection of monoclonal IgD-lambda M-protein in the serum and urine, markedly high activities of salivary-type amylase and NSE in the serum, and immunohistochemical evidence of NSE and IgD in the myeloma cells. After two courses of alpha-IFN and VMCP chemotherapy, serum IgD, amylase and NSE decreased to normal levels. These observations indicate that NSE was ectopically produced by myeloma cells.
一名68岁男性因全身乏力和厌食入院。基于血清和尿液中检测到单克隆IgD-λ M蛋白、血清中唾液型淀粉酶和神经元特异性烯醇化酶（NSE）的活性显著升高以及骨髓瘤细胞中NSE和IgD的免疫组化证据，他被诊断为患有产生NSE的IgD-λ型多发性骨髓瘤且血清淀粉酶活性高。经过两个疗程的α-干扰素和VMCP化疗后，血清IgD、淀粉酶和NSE降至正常水平。这些观察结果表明NSE是由骨髓瘤细胞异位产生的。
