Koizumi S, Kataoka Y, Inoue K, Kohzuma M, Niwa M, Taniyama K
Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan.
Neurosci Lett. 1995 Mar 3;187(2):123-6. doi: 10.1016/0304-3940(95)11341-x.
Pre-treatment with BAY K 8644, an L-type voltage-gated Ca2+ channels agonist, produced long-term enhancement (LTE) of over 2 h of high K(+)-evoked dopamine release from rat striatal slices. Exposure to BAY K 8644 under Ca(2+)-free conditions did not enhance this release. Thus, a transient activation of L-type voltage-gated Ca2+ channels followed by Ca2+ entry can trigger LTE of the evoked DA release from striatal tissues. This type of LTE in the striatum underlines the importance of presynaptic mechanisms, including L-type voltage-gated Ca2+ channels of 'long-term potentiation' expression.
用L型电压门控Ca2+通道激动剂BAY K 8644进行预处理，可使大鼠纹状体切片中高钾诱发的多巴胺释放产生超过2小时的长期增强（LTE）。在无钙条件下暴露于BAY K 8644并不能增强这种释放。因此，L型电压门控Ca2+通道的短暂激活随后Ca2+内流可触发纹状体组织诱发的多巴胺释放的LTE。纹状体中这种类型的LTE强调了突触前机制的重要性，包括“长期增强”表达的L型电压门控Ca2+通道。
