秋水仙碱和长春碱对博来霉素诱导的大鼠肺纤维化的影响。
The effect of colchicine and vinblastine on bleomycin-induced lung fibrosis in rats.
作者信息
Ledwozyw A
机构信息
Department of Pathophysiology, Veterinary Faculty of Agricultural Academy, Lublin, Poland.
出版信息
Acta Physiol Hung. 1994;82(4):383-9.
PMID:7540348
Abstract
The effect of colchicine and vinblastine on collagenase, lysyl oxidase and prolyl hydroxylase activities as well as on collagen cross-linking and types of this protein in bleomycin induced lung fibrosis in rats was investigated. Both colchicine and vinblastine diminish bleomycin-induced changes in the above-mentioned enzyme activities as well as collagen cross-linking and normalize type I/type III collagen ratio.
摘要
研究了秋水仙碱和长春碱对博来霉素诱导的大鼠肺纤维化中胶原酶、赖氨酰氧化酶和脯氨酰羟化酶活性的影响，以及对胶原蛋白交联和该蛋白类型的影响。秋水仙碱和长春碱均能减轻博来霉素诱导的上述酶活性变化以及胶原蛋白交联，并使I型/III型胶原蛋白比例正常化。
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