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[计算机形态密度测定法及其在实验和临床研究中的应用可能性]

[Computed morpho-densitometry and its possibilities in experimental and clinical studies].

作者信息

Kogan E M, Zhukotskiĭ A V, Kopylov V F, Lomakin O A, Molodtsov M Iu, Putina T G, Chernysh S A

出版信息

Vestn Ross Akad Med Nauk. 1995(3):33-40.

PMID:7540447
Abstract

The paper deals with the automatic morphodensitometric analysis of various biomedical objects (such as interphase chromatin in the cellular nuclei of chondroblasts and lymphocytes or human peripheral blood, opacities in the lens of chick embryos. A complex algorhythm of computational image processing was created for submolecular restructuring of interphase chromatin cell nuclear examinations. It includes specific methods of staining and unifies different quantitative analytical methods: photometrical, geometrical, gradiental, informational, and statistical. The blood cells of the children who had received low-dose radiation were detected by employing a new method of TV image computational processing of DNA-stained lymphocytes. The approach demonstrated by this study provides a sensitive and meaningful mean for diagnosing human diseases and can be useful in the clinical setting.

摘要

本文涉及对各种生物医学对象的自动形态密度分析(如软骨母细胞和淋巴细胞的细胞核中的间期染色质或人类外周血、鸡胚晶状体中的混浊物)。为间期染色质细胞核检查的亚分子重组创建了一种复杂的计算图像处理算法。它包括特定的染色方法,并统一了不同的定量分析方法:光度法、几何法、梯度法、信息法和统计法。通过采用一种对DNA染色淋巴细胞进行电视图像计算处理的新方法,检测了接受低剂量辐射儿童的血细胞。本研究展示的方法为人类疾病的诊断提供了一种灵敏且有意义的手段,在临床环境中可能会很有用。

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