Huang Z, Liang Y, Wu X
Department of Pathology, Medical College of Shantou University, Guangdong.
Zhonghua Bing Li Xue Za Zhi. 1995 Apr;24(2):90-2.
5 cases of basaloid-squamous carcinoma (BSC) of oesophagus were reported. Their pathological features were: 1. The main component of the tumors were basaloid carcinoma cells. 2. Concomitant squamous cell differentiation. 3. Comedo-like necrosis in the basaloid carcinoma component of the tumor. 4. Hyaline degeneration within the stroma of the basaloid carcinoma nests (PAS+). The immunohistochemistry of keratin 10.11, CEA and EMA in the basaloid carcinoma component of BSC were negative or weak positive, while actin and S-100 were positive in some parts of the tumor sections. This suggested that the carcinoma component was poorly differentiated and somewhat tended to differentiate toward myoepithelia or other directions. We therefore consider that the origin of BSC may be the primitive totipotential cell. BSC occurred more frequently in elderly males. The biological behavior of BSC was highly malignant. Regional lymph nodes or distant organ metastasis were usually found at the first operation. The mean survival period after operation was very short, BSC was therefore considered to be a specific clinicopathological entity.
报告了5例食管基底样鳞状细胞癌（BSC）。其病理特征为：1.肿瘤的主要成分是基底样癌细胞。2.伴有鳞状细胞分化。3.肿瘤基底样癌成分中存在粉刺样坏死。4.基底样癌巢间质内有透明变性（PAS+）。BSC基底样癌成分中角蛋白10、11、癌胚抗原（CEA）和上皮膜抗原（EMA）的免疫组化结果为阴性或弱阳性，而肌动蛋白和S-100在肿瘤切片的某些部位呈阳性。这表明癌成分分化差，且有一定向肌上皮或其他方向分化的倾向。因此，我们认为BSC的起源可能是原始全能细胞。BSC在老年男性中更常见。BSC的生物学行为具有高度恶性。首次手术时通常发现区域淋巴结或远处器官转移。术后平均生存期很短，因此BSC被认为是一种特殊的临床病理实体。
