Yoshioka K, Higashi Y, Yamada M, Aiyama T, Takayanagi M, Tanaka K, Okumura A, Iwata K, Kakumu S
Third Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Liver. 1995 Apr;15(2):57-62. doi: 10.1111/j.1600-0676.1995.tb00108.x.
Factors predicting the efficacy of interferon therapy were statistically analyzed on 111 patients with chronic hepatitis C. Of the treated patients (total doses of interferon; 96-468 MU), 35 (31.5%) had a long-term remission. On multivariate analysis, hepatitis C virus genotype (p < 0.0001), histological diagnosis (p < 0.05), fibrosis score of histological activity index (p < 0.01) and source of infection (p < 0.05) were found useful for predicting the response to interferon therapy. Our findings suggest that the outcome of interferon therapy can be predicted to some degree from pretreatment data, and that a new therapeutic strategy is necessary for the group of patients who are predicted to be nonresponders.
对111例慢性丙型肝炎患者进行了干扰素治疗疗效预测因素的统计学分析。在接受治疗的患者中（干扰素总剂量；96 - 468MU），35例（31.5%）实现了长期缓解。多因素分析显示，丙型肝炎病毒基因型（p < 0.0001）、组织学诊断（p < 0.05）、组织学活动指数纤维化评分（p < 0.01）和感染源（p < 0.05）对预测干扰素治疗反应有用。我们的研究结果表明，干扰素治疗的结果可以从治疗前数据中在一定程度上进行预测，并且对于预计无反应的患者群体需要一种新的治疗策略。
