Horneff G, Burmester G R
Zentrum für Kinderheilkunde Heinrich-Heine-Universität, Düsseldorf.
Z Rheumatol. 1995 Mar-Apr;54(2):96-104.
Rheumatoid arthritis is a chronic inflammatory disease mainly affecting the joints. The etiology is still unknown, but it shows several clinical and laboratory features of an autoimmune process. The conventional medical therapy consisting of a combination of analgetic and antiphlogistic agents with so called slow acting drugs is often not satisfactory and fails to persistently suppress disease activity. Therefore, therapeutic alternatives are necessary which are provided by a new generation of immunosuppressing agents including monoclonal antibodies. The paper will summarize some therapeutic approaches using monoclonal antibodies towards cell surface antigens or soluble mediators of inflammation for therapy of rheumatoid arthritis.
类风湿性关节炎是一种主要影响关节的慢性炎症性疾病。其病因尚不清楚，但呈现出自身免疫过程的若干临床和实验室特征。由镇痛药、抗炎药与所谓的慢作用药物联合组成的传统医学疗法往往不尽人意，无法持续抑制疾病活动。因此，包括单克隆抗体在内的新一代免疫抑制剂提供了必要的治疗选择。本文将总结一些使用针对细胞表面抗原或炎症可溶性介质的单克隆抗体治疗类风湿性关节炎的治疗方法。
