Doganov N, Dimitrov R, Iarŭkov A, Nachev A, Raĭcheva I, Bozhilov D
Akush Ginekol (Sofiia). 1994;33(3):23-4.
The study includes 56 cases of women admitted at Second gynaecology clinic of the University Maternity Hospital Sofia with evidence or suspicion of having an ectopic pregnancy who had their serum beta-HCG levels determined quantitatively. 27 of them showed no beta-HCG in their sera and none turned out to have pregnancy, neither intrauterine nor ectopic. All cases of ectopic pregnancies (a total of 20) were associated with detectable beta-HCG levels in the serum. The great diagnostic value of serum beta-HCG is emphasized in the cases of old disturbed ectopic pregnancies accompanied by mild and uncommon symptoms and very low beta-HCG levels. In case of unruptured pregnancies or tubal rupture the diagnosis is verified before the result is available by the clinical and sonographic data. On the other hand the high sensitivity of the method leads to an increased number of cases with elevated beta-HCG in which the location of the pregnancy cannot be proven. The precise quantitative evaluation of serum beta-HCG enables us to follow the tendency of beta-HCG which may according to the clinical manifestations warrant invasive diagnostic procedures or just observation without active interference.
该研究纳入了56例在索菲亚大学妇产医院第二妇科诊所就诊的女性，她们有证据或疑似患有异位妊娠，并对其血清β-HCG水平进行了定量测定。其中27例血清中未检测到β-HCG，且无一例妊娠，无论是宫内妊娠还是异位妊娠。所有异位妊娠病例（共20例）血清中β-HCG水平均可检测到。血清β-HCG在伴有轻微和不常见症状且β-HCG水平极低的陈旧性异位妊娠病例中具有重要诊断价值。在未破裂妊娠或输卵管破裂的情况下，临床和超声检查数据在结果出来之前就可以证实诊断。另一方面，该方法的高灵敏度导致β-HCG升高但无法证实妊娠部位的病例数量增加。血清β-HCG的精确定量评估使我们能够追踪β-HCG的变化趋势，根据临床表现，这可能需要进行侵入性诊断程序，或者只需观察而无需积极干预。
