Marck Y, Meunier L, Barnéon G, Meynadier J
Service de Dermatologie-Allergologie-Photobiologie, Hôpital St-Charles, Montpellier.
Ann Dermatol Venereol. 1994;121(10):712-4.
There are many causes of scleroderma. We observed a case of scleroderma involving the shoulder and neck area after combined bleomycin and radiotherapy.
After six cycles of a CHOP-bleo protocol followed by radiotherapy for lymph node lymphoma, a female patient presented scleroderma involving the shoulders and neck area. Total bleomycin dose was 252 mg.
Among the imputable factors, particularly extrinsic factors, in a series of 33 cases of different chemotherapy protocols published by Peters et al. in 1988, we retained the bleomycin radiotherapy administration sequence as the cause of this complication. Given after bleomycin, radiotherapy could increase the risk of scleroderma.
硬皮病有多种病因。我们观察到1例在使用博来霉素联合放疗后出现肩部和颈部硬皮病的病例。
一名女性患者在接受CHOP-博来霉素方案6个周期治疗后，接着进行淋巴结淋巴瘤放疗，之后出现累及肩部和颈部的硬皮病。博来霉素总剂量为252毫克。
在彼得斯等人于1988年发表的一系列33例不同化疗方案中，在可归咎因素中，尤其是外在因素方面，我们认定博来霉素与放疗的给药顺序是导致这一并发症的原因。放疗在博来霉素之后使用，可能会增加硬皮病的风险。
