Karlson K H, Ciampolillo-Bates F, McCoy D E, Kizer N L, Stanton B A
Department of Physiology, Dartmouth Medical School, Hanover, NH 03755, USA.
Biochim Biophys Acta. 1995 May 24;1236(1):197-200. doi: 10.1016/0005-2736(95)00068-e.
The cDNA sequence coding for the cGMP-gated cation channel expressed in the mouse kidney inner medullary collecting duct has been determined. The kidney cGMP-gated cation channel cDNA has an open reading frame of 2055 nucleotides and encodes a 685 amino acid protein. One cDNA clone is alternatively spliced thereby producing a deletion of 107 bp. Two differentially spliced 5' untranslated regions were determined by 5' RACE.
已确定在小鼠肾内髓集合管中表达的cGMP门控阳离子通道的cDNA序列。肾cGMP门控阳离子通道cDNA具有2055个核苷酸的开放阅读框，编码一个685个氨基酸的蛋白质。一个cDNA克隆发生选择性剪接，从而产生107 bp的缺失。通过5'RACE确定了两个差异剪接的5'非翻译区。
