Aloe L, Probert L, Kollias G, Micera A, Tirassa P
Institute of Neurobiology, Rome, Italy.
Rheumatol Int. 1995;14(6):249-52. doi: 10.1007/BF00262091.
We have previously shown an increase in nerve growth factor (NGF) levels and in mast cell (MC) distribution in the synovium of patients affected by rheumatoid arthritis. We now report that purified NGF antibodies injected into arthritic transgenic mice carrying the human tumour necrosis factor-alpha (TNF-alpha) gene caused reduction in the number of MCs, as well as a decrease in histamine and substance P levels within the synovium. These observations suggest that NGF antibody might be useful in studying the role of these pro-inflammatory markers in joint arthritis.
我们之前已经表明，类风湿性关节炎患者滑膜中的神经生长因子（NGF）水平和肥大细胞（MC）分布有所增加。我们现在报告，将纯化的NGF抗体注射到携带人类肿瘤坏死因子-α（TNF-α）基因的关节炎转基因小鼠中，会导致滑膜内MC数量减少，以及组胺和P物质水平降低。这些观察结果表明，NGF抗体可能有助于研究这些促炎标志物在关节关节炎中的作用。
