Coetzer J A, Louw T A
Onderstepoort J Vet Res. 1978 Dec;45(4):245-53.
The clinical symptoms, gross and histopathological, as well as the ultrastructural appearance of a condition in cross-bred Aberdeen Angus calves resembling the inherited lysosomal storage disease, alpha-mannosidosis, are reported. The neurones and perithelial cells in the brain and the reticuloendothelial cells in the lymph nodes and spleen were extensively vacuolated. The vacuoles were filled with a sparse, flocculated to granular material within which membranous structures were frequently seen. No specific substance could be identified within the vacuoles, either histochemically or ultrastructurally. Besides the vacuolation, cystic tubular structures were seen in the kidneys. The lining epithelial cells of the thyroid follicles were vacuolated while some of the follicles contained no colloid.
报告了杂交阿伯丁安格斯犊牛出现的一种病症的临床症状、大体和组织病理学表现以及超微结构特征，该病症类似于遗传性溶酶体贮积病α-甘露糖苷贮积症。大脑中的神经元和血管周细胞以及淋巴结和脾脏中的网状内皮细胞出现广泛空泡化。空泡内充满稀疏的、絮状至颗粒状物质，其中经常可见膜性结构。无论是组织化学还是超微结构检查，均未在空泡内鉴定出特定物质。除空泡化外，肾脏中还可见囊性管状结构。甲状腺滤泡的衬里上皮细胞空泡化，而一些滤泡不含胶体。
