右旋糖酐对庆大霉素所致耳毒性的影响。

Effect of dextran on gentamicin-induced ototoxicity.

作者信息

Manabe Y, Saito T, Tsuzuki H, Igarashi M, Yamagishi T, Saito H

机构信息

Department of Otolaryngology, Fukui Medical School, Japan.

出版信息

ORL J Otorhinolaryngol Relat Spec. 1995 May-Jun;57(3):111-4. doi: 10.1159/000276722.

DOI:10.1159/000276722

PMID:7541520

Abstract

The effect of low-molecular-weight dextran (DX) on gentamicin (GM)-induced ototoxicity was examined in guinea pigs. GM (100 mg/kg) was administered intramuscularly for 10, 12 and 14 days with or without DX. Cochlear damage was evaluated by compound action potential thresholds and surface preparation after fixation with osmium tetroxide. The percentage of missing outer hair cells was significantly increased by combined administrations of GM with DX. However, there was no significant difference in blood urea nitrogen levels in guinea pigs with or without DX. When aminoglycoside antibiotics and DX are administered together, attention should be paid not only to nephrotoxicity but also to ototoxicity.

摘要

在豚鼠中研究了低分子量右旋糖酐（DX）对庆大霉素（GM）诱导的耳毒性的影响。GM（100mg/kg）肌肉注射给药10、12和14天，同时给予或不给予DX。用四氧化锇固定后，通过复合动作电位阈值和表面制备评估耳蜗损伤。GM与DX联合给药显著增加了外毛细胞缺失的百分比。然而，给予DX和未给予DX的豚鼠血尿素氮水平没有显著差异。当氨基糖苷类抗生素和DX一起给药时，不仅应注意肾毒性，还应注意耳毒性。