Kirby R S
St Bartholomew's Hospital, West Smithfield, London, UK.
Scand J Urol Nephrol Suppl. 1995;168:29-33.
Benign prostatic hyperplasia (BPH) and hypertension are both common conditions in older men. It is estimated that 20 to 41% of middle-aged to elderly men may have both. Alpha-1 adrenoceptor antagonists, such doxazosin, produce significant improvements in urine flow rate and symptoms in patients with BPH. The effect of doxazosin on urine flow rate and symptoms in hypertensive men with BPH is similar to that seen in normotensive men. By contrast, doxazosin produces a significant fall in blood pressure in hypertensive men, but has minimal effect in normotensives. Doxazosin is well tolerated, irrespective of blood pressure status. Thus, it can be concluded doxazosin is an effective and well tolerated treatment for BPH which appears to have additional benefits in the management of patients with concomitant hypertension.
良性前列腺增生（BPH）和高血压在老年男性中都是常见病症。据估计，20%至41%的中年及老年男性可能同时患有这两种疾病。α-1肾上腺素能受体拮抗剂，如多沙唑嗪，可使BPH患者的尿流率和症状得到显著改善。多沙唑嗪对患有BPH的高血压男性的尿流率和症状的影响与血压正常男性相似。相比之下，多沙唑嗪可使高血压男性的血压显著下降，但对血压正常者影响极小。无论血压状况如何，多沙唑嗪的耐受性都很好。因此，可以得出结论，多沙唑嗪是一种治疗BPH的有效且耐受性良好的药物，对于合并高血压的患者似乎还有额外益处。
