Zúñiga-Pflücker J C, Jiang D, Lenardo M J
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
Science. 1995 Jun 30;268(5219):1906-9. doi: 10.1126/science.7541554.
CD25 expression occurs early in thymocyte differentiation. The mechanism of induction of CD25 before T cell receptor rearrangement and the importance of this mechanism for T cell development are unknown. In a thymus reconstitution assay, tumor necrosis factor alpha (TNF-alpha) and interleukin-1 alpha (IL-1 alpha), two cytokines produced within the thymic microenvironment, induced CD25 expression on early immature thymocytes. Either TNF-alpha or IL-1 alpha was necessary for further thymocyte maturation and CD4+CD8+ differentiation. In irradiated mice reconstituted with CD117+CD25+ thymocytes, commitment to the T cell lineage was marked by the loss of precursor multipotency.
CD25表达在胸腺细胞分化早期出现。在T细胞受体重排之前诱导CD25的机制以及该机制对T细胞发育的重要性尚不清楚。在胸腺重建试验中，胸腺微环境中产生的两种细胞因子，肿瘤坏死因子α（TNF-α）和白细胞介素-1α（IL-1α），可诱导早期未成熟胸腺细胞上的CD25表达。TNF-α或IL-1α对于胸腺细胞的进一步成熟和CD4+CD8+分化是必需的。在用CD117+CD25+胸腺细胞重建的辐照小鼠中，向T细胞谱系的定向分化以祖细胞多能性的丧失为标志。
