Gillam S
Department of Pathology, University of British Columbia Research Centre, Vancouver, Canada.
Biochem Cell Biol. 1994 Sep-Oct;72(9-10):349-56.
Rubella virus is a small, enveloped, positive-stranded RNA virus in the Togaviridae family and bears similarities to the prototype alphaviruses in terms of its genome organization and strategy for viral gene expression. Despite being an important human pathogen, the cell biology of rubella virus remains poorly characterized. This review focuses on the molecular biology of rubella virus structural proteins, with emphasis on the proteolytic processing and maturation of virus structural proteins, the glycosylation requirement for intracellular transport and function of glycoproteins, and the localization of hemagglutinin- and virus-neutralizing epitopes. A number of significant differences between rubella virus and alphavirus structural protein expression and maturation were discovered.
风疹病毒是披膜病毒科中的一种小型有包膜的正链RNA病毒，在基因组结构和病毒基因表达策略方面与原型甲病毒相似。尽管风疹病毒是一种重要的人类病原体，但其细胞生物学特性仍知之甚少。本综述着重于风疹病毒结构蛋白的分子生物学，重点关注病毒结构蛋白的蛋白水解加工和成熟、糖蛋白细胞内运输和功能的糖基化要求，以及血凝素和病毒中和表位的定位。发现了风疹病毒与甲病毒结构蛋白表达和成熟之间的一些显著差异。
