整合素受体α8β1介导胚胎期鸡运动神经元和感觉神经元与腱生蛋白-C的相互作用。
The integrin receptor alpha 8 beta 1 mediates interactions of embryonic chick motor and sensory neurons with tenascin-C.
作者信息
Varnum-Finney B, Venstrom K, Muller U, Kypta R, Backus C, Chiquet M, Reichardt L F
机构信息
Department of Physiology, University of California, San Francisco 94143-0724, USA.
出版信息
Neuron. 1995 Jun;14(6):1213-22. doi: 10.1016/0896-6273(95)90268-6.
Abstract
This paper identifies a neuronal receptor for tenascin-C (tenascin/cytotactin), an extracellular matrix protein that has previously been detected in developing sensory and motor neuron pathways and has been shown to regulate cell migration in the developing CNS. Antibodies specific for each subunit of the integrin alpha 8 beta 1 are used to demonstrate that alpha 8 beta 1 mediates neurite outgrowth of embryonic sensory and motor neurons on this extracellular matrix protein. In addition, expression of alpha 8 in K562 cells results in surface expression of alpha 8 beta 1 heterodimers that are shown to promote attachment of this cell line to tenascin. The major domain in tenascin that mediates neurite outgrowth is shown to be localized to fibronectin type III repeats 6-8.
摘要
本文鉴定了腱生蛋白-C（腱生蛋白/细胞触珠蛋白）的一种神经元受体，腱生蛋白-C是一种细胞外基质蛋白，此前已在发育中的感觉和运动神经元通路中检测到，并且已证明其可调节中枢神经系统发育过程中的细胞迁移。使用针对整合素α8β1各亚基的特异性抗体来证明α8β1介导胚胎感觉和运动神经元在此细胞外基质蛋白上的轴突生长。此外，α8在K562细胞中的表达导致α8β1异二聚体在表面表达，已证明该异二聚体可促进此细胞系与腱生蛋白的附着。腱生蛋白中介导轴突生长的主要结构域定位于纤连蛋白III型重复序列6-8。
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